e innovative microtopography and nanotopography laser-induced surface showed high biocompatibility with primary human osteoblast cultures and the absence of impurities. The innovative laser texture was capable of influencing the osteogenic process, confirming the critical role of titanium surface characteristics in the cell adhesion and bone deposition during the early phases of osseointegration. The association of human adipose stem cells and titanium surfaces laser-induced with an innovative procedure could generate promising improvements and developments in orthopedics, maxillofacial, and dental implant surgery.PURPOSE Bone regeneration procedures are often evaluated based on biologic aspects only. As regenerated bone also has to ensure primary implant stability, the goal of this study was to determine the mechanical quality of regenerated bone. https://www.selleckchem.com/products/pkm2-inhibitor-compound-3k.html MATERIALS AND METHODS Six adult minipigs were allocated for this experiment with four mandibular study sites each established following tooth removal. Two different types of bovine bone mineral as well as autogenous bone were used for augmenting three-walled defects, while native bone served as the control. Implants were placed after 12, 18, and 24 weeks of healing, and bone quality was determined using intraoperative compressive testing (BoneProbe), insertion torque measurements, and resonance frequency analysis. The mandibles were then harvested for determining bone mineral density (BMD) and bone-to-implant contact (BIC). Statistical analysis was based on two-way analysis of variance of aligned rank transformed data and Spearman's rank correlation tests (α = .05). RESULTS The effects of the factors healing time and material on the parameters tested were too small to be significant (P ranging from .34 to .98). Weak correlations were observed for implant insertion torque with BoneProbe measurements in the cortical (0.481; P = .032) and in the trabecular area (0.639; P = .002). BoneProbe measurements in the trabecular part and in the cortical part also correlated with each other (0.477; P = .035). CONCLUSION While differences may exist between bone regenerated using different biomaterials with respect to biologic behavior, differences in the mechanical properties determining primary implant stability seem to be minor. Implant insertion torque measurements appear to be a reliable tool for determining bone quality if only one specific implant type is considered.PURPOSE To analyze the impact of microthreads on the stresses generated in peri-implant bone surrounding reduced-diameter zirconia and titanium implants under loading. MATERIALS AND METHODS Two custom-made zirconia implants, microthreaded or smooth neck, and two titanium replicas were made. Strains were recorded in the peri-implant region under 200-N vertical load. Two three-dimensional finite element models were created. Zirconia and titanium implants were tested under 200-N vertical load and 150-N oblique load at 30, 45, and 60 degrees. RESULTS The lowest peri-implant strain (40 ± 6 με) under vertical load was related to the microthreaded zirconia implant. Oblique load showed higher von Mises stress on bone in comparison with vertical load. The von Mises stress increased by increasing the load angle by approximately 2 MPa per degree. Under oblique load, implants showed more stress in peri-implant bone and the implant itself. On the other hand, total strains were within physiologic limits in all tested cases. CONCLUSION Stresses within the peri-implant cortical bone around the reduced-diameter implant with microthreads appeared to be superior compared with the smooth-neck one. Reduced-diameter zirconia implants induced less stress on bone in comparison with the titanium implants, suggesting that zirconia is a feasible alternative for titanium.PURPOSE The goal of this study was to compare bone graft materials in mandibular third molar extraction sockets and to monitor bone remodeling and complications. MATERIALS AND METHODS Patients with bilateral, impacted mandibular third molars were involved. Twenty-four patients were planned to be randomly assigned to three possible treatments (1) the control sockets were left empty; (2) the socket was filled with bovine xenograft (Bio-Oss); or (3) the socket was filled with albumin-impregnated bone allograft (BoneAlbumin). Postoperative pain during the first week was determined with the visual analog scale. Cone beam computed tomography (CBCT) images were taken at 6 and 12 weeks and 1 year postoperatively for micromorphologic analysis and measurement of pocket depth at the second molar. Patients and image analyses were blinded toward the treatment group (randomized double-blind split-mouth design). RESULTS Postoperative pain was lowest in the allograft group (control 5.06 ± 0.53; xenograft 5.85 ± 0.42; allograft 3.94 ± 0.52; P less then .05). At weeks 6 and 12, early signs of remodeling were observed in the allograft group and the controls, while bone xenograft was still demarcated from the host bone. The 1-year CBCT images showed complete remodeling and integration of allograft with natural trabecular structure, while the xenograft particles were still visible. Support for the second molar was significantly better, as evidenced by less deep and prevalent pockets in the allograft-filled group compared with the controls (P = .017). CONCLUSION Filling an extraction socket with albumin-integrated allografts provides superior bone regeneration compared to either native bone buildup or xenograft application or socket regeneration without bone grafting.PURPOSE To evaluate the interobserver and intraobserver agreement between prosthodontists when measuring interproximal peri-implant bone levels from digital periapical radiographs and to introduce a radiographic quality index for periapical imaging assessment. MATERIALS AND METHODS Periapical radiographs of 122 single implants in the anterior and posterior regions with two categories of imaging quality (ie, optimal and suboptimal) were assessed. Six prosthodontists were asked to linearly measure the distance from the first bone-to-implant contact to the implant platform/shoulder (DIB) using an image processing program (ImageJ 1.48u4, NIH). The procedure was repeated after 3 to 4 weeks. Interobserver and intraobserver agreements were evaluated by intraclass correlation coefficient and kappa. A radiographic quality index developed for periapical imaging assessment has been introduced in this study. Each implant was classified into two categories according to the implant type and the quality of the radiographic image.